Having these medications with divalproex sodium could reduce the extent of divalproex sodium in Your system. Consequently it may well not get the job done too to take care of your ailment.
Tend not to prevent Depakote without 1st speaking with a healthcare company. Stopping Depakote instantly can result in major challenges. Halting a seizure medication quickly inside of a client that has epilepsy may cause seizures that won't prevent (position epilepticus).
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This medication did not clearly show effectiveness in kids for mania. It shouldn’t be Employed in those with mania who are young than eighteen a long time.
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Depakote may cause major Negative effects which include: See “What is The main information and facts I ought to learn about Depakote?”
Prescribers really should watch serum valproate concentrations and clinical response when incorporating or discontinuing estrogen that contains goods.
Other Unwanted effects not shown may additionally take place in some patients. If you see almost every other results, Verify with your Health care Specialist.
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have or Consider there is a genetic liver issue due to a mitochondrial problem including Alpers-Huttenlocher syndrome.
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twelve.2 Pharmacodynamics The connection involving plasma concentration and scientific reaction just isn't nicely documented. A person contributing component could be the nonlinear, concentration dependent protein binding of valproate which has an effect on the clearance on the drug. Hence, checking of whole serum valproate can not give a reputable index from the bioactive valproate species.
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are pregnant or could turn into Expecting. DEPAKOTE may well hurt your unborn baby. See “two. Depakote may harm your unborn baby” earlier mentioned To learn more.